Took a few hours earlier and slept well, but having fallen asleep in a sitting position, in my computer chair. So I woke from my nap/OC+chlormethiazole&clonidine nod with my arse feeling like it had been run through a blender full of rusty nails and battery acid.
And my hip...christ. It was fucking bellowing in rage at me afterwards for being treated like that, usually its only howling miserably, or if I am lucky, and the pharmacies all serve some J.Collis.Browne's mixture to top off my script (over the counter morphine, not massively strong, but a respectable 20mg per little bottle), or if as I almost always do, buy micron filters so I can safely inject my oxycontin pills then it might, just might shut the flying fuck up for a few hours.
Still sore though now, after the 40mg by mouth a soon as I scored from the pharmacy, plus 80mg I had hours earlier, and a further 40 on waking up with my arse wishing it was somebody else's (hey, DFG, miss K? burned one? any chance of borrowing one?
)
*polishes halo*
Having been without my chlormethiazole rx for 3-4 days, my tolerance against expectations actually dropped quicker than I would ever have a GABA agonist would without my having...prompted...them, neuropharmacologically speaking.
Almost any sleep aids, of the kind that work on the GABA system, require quite a while to reset the downregulation of endogenous inhibitory tone back to pre-medication levels.
Sometimes this can result in PAWS, short for post-acute withdrawal syndrome, where a patient, alcoholic, benzo addict etc. I'm neither, mind 'ye, what happens though, is in response to either benzos (which bind to a seperate allosteric site on the benzodiazepine-sensitive populations of GABAa, stabilizing a conformation that results in the binding of GABA with increased affinity, even if plastic changes mean there is less actual neurotransmitter to go around...and of course there are the GABAb, GABAc receptors that need their helping too.
The body can compensate for additional stimulation by reducing GABA release, and gets used to doing so, although it essentially forgets that 'hey, this walks like homeostasis, talks like homeostasis, smells like it from a distance. But it is nothing of the kind'.
PAWS results from the failure to restore proper inhibitory tone and may last years, and sounds vicious.
W/D from Chlormethiazole, like the barbs is worse, an allosteric positive modulator still, isssuss but rather than just making GABA more effective, barb binding site (the same site that docks the antagonist picrotoxin, a nasty inverse agonist convulsant panicogen)
Barbs act on the same reeptor, although thrrough different populations and subtypes (there are a a veritable stack of them, which colocalize in heteropentamers, they have the ability to gate the chloride ion channel directly, which sits in the center of the aforesaid receptors, to open and pass an inhibitory current of chlorine, reducing neuronal excitability.
The body has no effective way of saying 'hey fuck you, this is more than I can take'
And ends up going from 'gag', 'puke', 'die'->'collect halo'
(credit where it is due,, that quote comes from kassiane/rettdevil, the autie activist, generally funny fucker, and, dare I say it, drop-dead yummy looking lady:))
