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Author Topic: What have you done today? (Pt 2)  (Read 157189 times)

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Offline odeon

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Re: What have you done today? (Pt 2)
« Reply #4500 on: December 22, 2013, 04:13:42 AM »
Quote from: Parts on December 20, 2013, 06:42:37 PM
I broke a light bulb with my head at work :tard:  I was on my stilts and stepped backwards hitting it with the back of my head, at least it wasn't on ,  and no it wasn't the first time this has happened  :LOL:

:laugh:

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Offline Lestat

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Re: What have you done today? (Pt 2)
« Reply #4501 on: December 22, 2013, 09:02:44 AM »
Read, read more, and more other stuff.

Came up with a bit of a novel idea for making alpha-substituted tryptamines from tryptophan

(Hell-Vollhard-Zelinzki rxn using catalytic PBr3, mol. eq. Br2 to halogenate the alpha position of tryptophan (or 5-HTP if serotonin analogs were aimed for, or more interestingly, alkylate that hydroxyl first on 5-HTP), followed by displacement of halide by a tosylate ester, such as, for ex. AMT, methyl tosylate, then decarboxylation of the tryptophan to (alpha-alkyl)tryptamine.

Methyl tosylate is pretty poisonous stuff, but then again, it wouldn't be a good idea to breathe/get splashed by Br2 or phosphorus tribromide either. Although probably much less likely to prove lethal.

I think it should work, certainly plan to give it a shot. I love AMT, cracking psychedelic/entactogen material for me personally, although some people find it rough, and its known to be a bit of a gutbuster for many especially at higher levels. Quite variable as to peoples response to dosage also, but for those who it seems to agree with, seems to be well liked.
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Offline odeon

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Re: What have you done today? (Pt 2)
« Reply #4502 on: December 22, 2013, 03:17:23 PM »
Swept floors and did some general dusting of things. Watched an episode of Cosmos and realised the world desperately needs a new Carl Sagan. Posted here.
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Offline Parts

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Re: What have you done today? (Pt 2)
« Reply #4503 on: December 22, 2013, 06:14:24 PM »
Did some deep cleaning around the house since everyone was out for the day
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Offline Lestat

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Re: What have you done today? (Pt 2)
« Reply #4504 on: December 22, 2013, 07:28:31 PM »
Bah I derped with my idea. Amine would need protecting certainly. And given the mechanism of the Hell-Volhard-Zellinski, Not sure if it would be amenable to protect the amine prior to reaction, amongst other things.

I need to dig out my ebooks on protecting groups and do some digging, and some scheming.
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Offline "couldbecousin"

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Re: What have you done today? (Pt 2)
« Reply #4505 on: December 22, 2013, 08:41:42 PM »
  I replaced three lightbulbs in my apartment with the energy-efficient ones my boss gave me.  :thumbup:
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Offline Queen Victoria

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Re: What have you done today? (Pt 2)
« Reply #4506 on: December 22, 2013, 08:55:09 PM »
This week I had to do some frenetic re-arranging of piles to have the new TV and internet access installed.  I set a goal that by tomorrow I would go through the 3 clothes baskets I put by PA's bed.  Accomplished.  Result: trash and thrift store donations were accumulated.

Had a clearing of the air after a bit of a tiff with PA. 
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Offline "couldbecousin"

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Re: What have you done today? (Pt 2)
« Reply #4507 on: December 22, 2013, 08:56:03 PM »
Quote from: Queen Victoria on December 22, 2013, 08:55:09 PM
This week I had to do some frenetic re-arranging of piles to have the new TV and internet access installed.  I set a goal that by tomorrow I would go through the 3 clothes baskets I put by PA's bed.  Accomplished.  Result: trash and thrift store donations were accumulated.

Had a clearing of the air after a bit of a tiff with PA.

  Clearing space and clearing the air, a day well spent.  :thumbup:
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"I'm finding a lot of things funny lately, but I don't think they are."
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"We are grateful for the time we have been given."
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Offline odeon

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Re: What have you done today? (Pt 2)
« Reply #4508 on: December 25, 2013, 10:08:59 AM »
Watched several episodes of Sherlock Holmes with Jeremy Brett starring in the title role. Brett's is the finest Holmes to date, IMHO.
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"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."

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Offline Pyraxis

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Re: What have you done today? (Pt 2)
« Reply #4509 on: December 25, 2013, 10:36:07 AM »
Watched Christmas movies with WolFish while eating ham and cornbread.
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Offline Gopher Gary

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Re: What have you done today? (Pt 2)
« Reply #4510 on: December 25, 2013, 11:21:26 AM »
I did a Merry Christmas!! :GA:
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Offline Queen Victoria

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Re: What have you done today? (Pt 2)
« Reply #4511 on: December 25, 2013, 12:17:39 PM »
Now that we have BBC America, I'm Dr. Whoing  Dr. Who.

Translation - since you have to take DW as you find him, rapid speech with the occasional heavy accent and convoluted story lines, I just watch him for enjoyment.  I'm able to get 10 or 15 minutes or more here and there and just enjoy.
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Offline Semicolon

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Re: What have you done today? (Pt 2)
« Reply #4512 on: December 25, 2013, 08:58:48 PM »
Quote from: odeon on December 25, 2013, 10:08:59 AM
Watched several episodes of Sherlock Holmes with Jeremy Brett starring in the title role. Brett's is the finest Holmes to date, IMHO.

:orly:

Better than everyone else on this list? :nerd!:
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Offline Parts

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Re: What have you done today? (Pt 2)
« Reply #4513 on: December 25, 2013, 09:46:08 PM »
Had company over then went to my sisters
Came home and had more people over
 :GA: :GA: :GA:
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Offline odeon

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Re: What have you done today? (Pt 2)
« Reply #4514 on: December 26, 2013, 04:29:56 AM »
Quote from: Semicolon on December 25, 2013, 08:58:48 PM
Quote from: odeon on December 25, 2013, 10:08:59 AM
Watched several episodes of Sherlock Holmes with Jeremy Brett starring in the title role. Brett's is the finest Holmes to date, IMHO.

:orly:

Better than everyone else on this list? :nerd!:

Well, of the ones I have seen, yes.
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