Aw
Scratch behind his ears for me Ren?
As for me, got my eyes on a couple of gallon jugs of dichloromethane.
I've been reading a couple interesting little articles too, and they are making me want some tosyl chloride, and the other paper, making me REALLY want some sodium azide, the stuff they use as the gas generating chemical in car airbags as the propellant charge. Its a reagent to be careful with, for more than one reason. It can deflagrate if ignited or subjected to impact/friction or direct flame, although it doesn't detonate, the alkali metal azides and alkaline earth metal azides don't, they just deflagrate, go up in a big plume of rapidly expanding hot gases and alkali/alkaline earth metal bits.
Also, the azide anion is highly toxic, the level of and mechanism of toxicity both being similar to that of cyanide, inhibition of the electron transport chain and choking up cellular respiration. Can kill very quickly in case of poisoning, and lastly, one has to be very, very, very careful to avoid solutions of sodium etc. azide coming into contact with solutions of lead salts, mercury salts and other heavy metal salts, and also avoid contact with transition metal salts. This is because things like lead azide can precipitate out, which are, unlike sodium and the rest of the alkali metal azides, lead azide and other heavy and IIRC (not sure, would have to look it up first, but obviously I would rule out such hazardous interactions before allowing NaN3 to interact with a transition metal compound, it would have to be confirmed in advance that such a transition metal azide WASN'T a sensitive primary explosive before any reaction with azides involving transition metals, knowing what I do about heavy metal azides. They used to use lead azide in bullet primers, like mercury fulminate, in the part of the primer cap that the gun's hammer strikes, igniting the lead azide and causing it to detonate, igniting the propellant powder charge.
So of course care is vital.
In this case its not for anything explosive-related at all though, but for some organoazide chemistry directed at very high yielding, clean and rapid synthesis of isocyanates from aldehydes via Curtius rearrangement of an intermediate acyl azide, meant to give very high yields, very quickly too and cleanly as well.
And depending or not on whether the steric constraints on some specific molecules that permit their not having EXTREME instability (not explosively, just in terms of their having a tendency, as some similar molecules do, to polymerize and turn to totally useless utter crap, of a completely unsalveagable nature, I.e once it happens, if it does, 'now you've gone and done it', nothing for it but to start the synthesis all over again and hope you can manage it the next time round, if the steric protection methods usable to arrest this process can bee made to coincide with the steric and electronic constraints which allow for receptor binding (as an [ideally decent efficacy and potency partial] agonist) at certain selected target sites, then I ought to give myself some lessons in making azidoketones; I've been having quite a few interesting ideas of late.
Oh, and I want to buy (and REALLY sure as shit stinks, do NOT wish to make, because its nasty as hell, dangerously corrosive stuff, extremely strong acid, fumes in air, and reacts very violently with water, dangerously violently, and synthesizing it....no thanks, IIRC it involves something like chlorinating sulfur trioxide (sulfuric acid anhydride), whilst dissolved in anhydrous fuming sulfuric acid, so buying it is definitely the best option) myself some chlorosulfonic acid.
Also some imidazole, as well as some oleum (fuming concentrated sulfuric acid with additional SO3 dissolved in it), because of this really, REALLY neat sounding ionic liquid based on a disulfonated imidazole structure, apparently the nitrate salt can do some pretty wondrous things vis a vis forming, at room temperature, conjugated nitroalkenes in super-mild conditions directly from the corresponding alpha,beta-unsaturated alkene compounds. I've never heard of a reagent which would permit that before, The ionic liquid itself looks rather a bitch to make, given the nasty things one needs to use to make it in the first place, but once that is done, it ought to be reusable, just re-form the nitrate salt, but the disulfonylimidazole part of this specific ionic liquid, the ionic liquid itself, once you've got it, you've got it and it can be recycled, should just need, after use, to be reacted with some nitric acid. And since I've got IIRC a couple of pounds of sodium nitrate (forget the exact weight I have of NaNO3, but plenty enough) I can simply distill a mixture of sodium nitrate and concentrated sulfuric acid together, and the distillate collected in the receiver will be concentrated nitric acid:)
(I would have white fuming nitric acid on my wish list, but it isn't going to be since I can make WFNA any time I want, nitrate salt, concentrated sulfuric acid, boil it all up together and distill and I've got all the fuming nitric acid I could eat, metaphorically speaking of course, since HNO3, fuming or otherwise, of either colour, are not what you could call high on my list of culinary treats I'm just aching to try:autism:)
