Just one quick bitch, part two

[renaeden]

Amisulpride sounds interesting because it isn't as sedating as other antipsychotics but as I don't have schizophrenia or psychosis it would be expensive (not on the PBS, meaning it would cost more than $6).

Not too keen on benzos and opioids.

[Lestat]

Really just about anything would be superior to haloperidol, due to its longterm, and serious tox issues.

[renaeden]

Even at a low dose such as mine?

[Lestat]

Well its a longterm issue with haldol, not due exactly to the drug itself, to its toxic metabolite, HPP, which like MPTP, is uptaken into dopaminergic neurons, specifically targeting those of the nigrostriatal tract, entering nerve cells in the substantia nigra, and when those kinds of toxins get into cells, they are converted to a charged metabolite, such as HPP+ or MPP+ via monoamine oxidase, IIRC its MAO-b which does this, and then due to being charged, the metabolite cannot leave the cell, and quite literally 'fries' and destroys the nerve cell.

Loperamide (immodium) the antidiarrhea drug also has a metabolite with similar properties, although in adults, loperamide doesn't get to go fuck the brain a new arse ring because its uptaken past the BBB, but immediately gets pumped back out again by P-glycoprotein, a multidrug efflux pump. It cannot be given to newborns or very young children for this reason, tox studies in immature piglets which lack a fully-formed blood-brain barrier have shown lethality when given loperamide.

A chronic, low-dose of such a toxin, acting in the way it does, is still going to cause damage. Personally, I think haldol should have been, and still should be taken off the market entirely. There are enough APs, both typicals and atypicals, with a widely varying selection of activities, that it just has no good reason to remain in clinical use.

http://www.docguide.com/haloperidol-not-olanzapine-linked-brain-shrinkage-schizophrenia-presented-sfn


http://www.ncbi.nlm.nih.gov/pubmed/15756305 Similar comparative study in rhesus monkeys, chronic treatment, olanzapine and haloperidol, as well as placebo compared.

Look around, IMO the longterm effects of APs are quite scary.

[DirtDawg]

Fucking narrow-minded bigots.

Not sure to whom you are referring, but if, on that night, I had had a chance to be mellow and sober up some; if I had been left alone, things would not have progressed as they did.


... or if you have another subject in mind ...

["couldbecousin"]

I want my sniff, dammit, the bag I didn't finish shooting the other night. I KNOW I didn't just tan it and forget, I KNOW its here somewhere, but I just don't know where.

I'd love a wee bedtime midnight snack (well almost 6am snack actually) of a nice fat bellringer of a hit of IV coke, or maybe cook up a couple of rocks. Hell and buggery, maybe both.

I want my feckin' ching damnation, arsery and fucknuggets take its hiding place, grrr!
And I AM going to find it and have a quick dig before I get my kecks off and in bed proper (as opposed to just lounging around on my arse looking INSIDE the bed, and quilt that is)

Fucked if I am not going to find that bolivian marching powder before I go to sleep, sleeping pills/morphine or no sleepers/morphine.

  You'll probably find it next week, and post about it in the  "something good that happened today"  thread. 

["couldbecousin"]

Being naked didn't entice any of you, so I guess I will put on some clothes...dammit!!!

Did I miss someone's n00ds?

  Your avatar is a n00d.  Just sayin'. 

[DirtDawg]

I can't sleep.

That's because it's not bedtime in America.   

Correct.

I fucking hate jetlag.

On the other hand, you can post at the same time as the Americans.

That would be nice, because NOBODY seems to post often when I am here.

Move to Sweden.

Remember to bring extra ammo, to share with the Swedes.

Do NOT dare remove AMMO from these states.

You can give them a few guns, but do not DARE REMOVE AMMO FROM THESE SHORES!

[DirtDawg]

Well its a longterm issue with haldol, not due exactly to the drug itself, to its toxic metabolite, HPP, which like MPTP, is uptaken into dopaminergic neurons, specifically targeting those of the nigrostriatal tract, entering nerve cells in the substantia nigra, and when those kinds of toxins get into cells, they are converted to a charged metabolite, such as HPP+ or MPP+ via monoamine oxidase, IIRC its MAO-b which does this, and then due to being charged, the metabolite cannot leave the cell, and quite literally 'fries' and destroys the nerve cell.

Loperamide (immodium) the antidiarrhea drug also has a metabolite with similar properties, although in adults, loperamide doesn't get to go fuck the brain a new arse ring because its uptaken past the BBB, but immediately gets pumped back out again by P-glycoprotein, a multidrug efflux pump. It cannot be given to newborns or very young children for this reason, tox studies in immature piglets which lack a fully-formed blood-brain barrier have shown lethality when given loperamide.

A chronic, low-dose of such a toxin, acting in the way it does, is still going to cause damage. Personally, I think haldol should have been, and still should be taken off the market entirely. There are enough APs, both typicals and atypicals, with a widely varying selection of activities, that it just has no good reason to remain in clinical use.

http://www.docguide.com/haloperidol-not-olanzapine-linked-brain-shrinkage-schizophrenia-presented-sfn


http://www.ncbi.nlm.nih.gov/pubmed/15756305 Similar comparative study in rhesus monkeys, chronic treatment, olanzapine and haloperidol, as well as placebo compared.

Look around, IMO the longterm effects of APs are quite scary.

'kay, try having three big shots forced on you in the thigh, then the shoulder, then the jugular.
Spend the night in Intensive Care because they are sure they gave you too much. Then waking up about an hour later with your doctor standing over you saying to the attending physicians, "Wow, I usually don't see me fifty year old fathers in this kind of shape. What the hell happened?"

I sat up and said, "They injected me with  bunch of goddamn drugs I did not need. I told them I just needed to sleep it off. I am drunk!"

He was startled, looked at the attending and said " I thought you said you had given him four hundred fifty mg of halo! He should be asleep for  almost twenty four hours!"  " Yes, I hit him three times with one hundred fifty mg each time. He should be asleep!"
I said, "Before we go on, I really need to pee!"

Doc said, "I will see you in the morning. Quit struggling against those restraints and get some sleep, please."


It was a really long night.

[DirtDawg]

Hey DD, I take haloperidol (willingly though, and not injected). That sounds like some experience.

My quick bitch is that the Social Media class I have taken is from a public relations perspective and I have to give a speech about it in a few weeks. I am dreading it.

I understand.  You take a small dose all the time. This is described for a number of causes.

Having a massive dose forced on you is a different matter.  A massive dose is considered to be an anti-psychotic. I must have seemed quite mental, after my behavior.
But, hey, three big ass shots put me out for almost an hour.

I was punked!
 

[Lestat]

Been looking for that fucking bag ever since, CBC. Still haven't found it.

Get paid today, so will just get some more. Although I'd love to find it tonight, I'm bored as fuck. Might have to have a root around to see if I can locate it.

[Pyraxis]

Not sure to whom you are referring, but if, on that night, I had had a chance to be mellow and sober up some; if I had been left alone, things would not have progressed as they did.


... or if you have another subject in mind ...

Totally different subject. I was referring to the narrow-minded bigots throughout the world who have ensured that gay and lesbian couples considering foreign adoptions need to have one member of the couple deal with the agency, claiming to be a single parent, because of the number of countries that block adoption to homosexual couples. Even Thailand is changing its rules for gay couples, so they're looking to India instead.

[Semicolon]

Correct.

I fucking hate jetlag.

On the other hand, you can post at the same time as the Americans.

That would be nice, because NOBODY seems to post often when I am here.

Move to Sweden.

Remember to bring extra ammo, to share with the Swedes.

Do NOT dare remove AMMO from these states.

You can give them a few guns, but do not DARE REMOVE AMMO FROM THESE SHORES!

What will they shoot out of the guns?



We already export billions of dollars of weapons per year. Why not send the Swedes a few bullets?

[Lestat]

Whilst it isn't a closeup, I used to (lost it when I got nicked once by the filth) have the exact same bayonet, only without a fuller groove. Made for a great long sheath knife/dagger, really comfy solid grip to it.

[odeon]

Feeling a bit jittery.