sorry you had to go through that. Some of those psych meds are awful, I am SERIOUSLY intolerant of dopamine D2 antagonists, they make me really ill. That and (was given this for sleep once)...arrgh what the fuck is that tetracyclic antidepressant, the most potent sedating antihistamine on the market/alpha2 adrenergic autoreceptor antagonist (alpha2 antagonists make me just as ill as neuroleptics), never needed the latter for psych reasons, but they are used as antivomiting agents, got given IIRC trifluoroperazine once after a bout of awful food poisoning and if it wasn't awful enough to start with I just wanted to DIE after taking that shit. The rest of it went down the toilet. Even domperidone, which is a much less potent D2 antagonist, not meant to cross the blood-brain barrier, still manages to make me want to go find a high place with lots of rocks underneath to jump off whilst wearing a backpack full of ball bearings and nitroglycerin.
I hope so much the PR doesn't get affected by those awful meds that way, I'd hate for her to suffer like that. Well I hate the idea of her being even slightly unhappy, but you know what I mean.
*hugs for both of you QV and PR*
What seizure meds does she take (IF of course, she agrees to say, please, ask her before telling me, in case she prefers for that to be personal and private), because some of them aren't at all bad. Quite a lot of them, although depending on the type, some of the major families are calming agents too, like valium, phenobarb, and all the other benzos and similar used for seizure control. The one I take, chlormethiazole is actually quite pleasant, could be used recreationally (indeed, have tried it that way and its really quite a good recreational, a homespun lot of course so as not to waste the stuff I need for seizure control. Had to take an additional dose of that earlier, after..well not an aura exactly, it went straight from business as normal to beginning of a myoclonic seizure, but thanks to the chlormethiazole extra capsule, that did a wonderful job of shorting it out before it ever got to be more than a few twitches, a little difficulty grabbing the pill bottle off the coffee table due to the seizure trying to start. Chlormethiazole is kinda like a barbiturate in the way it acts on GABAa receptors, rather than like a benzo or Z-drug, in terms of binding site and the way it modulates the gating of the ion channel, and with a similarly hefty kick to the barbs (albeit I've only tried two of those, they aren't common now at all, I'd have to make them if I wanted to try others, but phenobarb, which is pretty shitty, more of a knock on the head with a lead pipe, minus the headache and broken face
, and the first of the barbs to be discovered, barbital itself, which despite the long acting nature is actually pretty fun stuff. Got hold of a bit over an ounce of the stuff, as lab grade powder, from a genetics/biotech lab from an old contact who worked there, and used it for making PH buffer systems for cell cultures.
But chlormethiazole works great for the seizures. REALLY fucking fast too, once the capsules let their contents out, absorption seems to be within minutes, at least as fast as one begins to feel alcoholic spirits after drinking say, a coffee mug full of dark rum in one shot. So its kinda just down the hatch, and moments later, seizure aborted. Love the stuff in that respect. Pretty good at making sure I get a good night's sleep too, as its also used as a sleeping pill and alcohol detox drug for its sedative-hypnotic effect.
And unusually, quite astonishingly in fact for a GABAergic agonist, I've had NO physical dependency from even years of use several times a day, and I know of NO other drug, other than perhaps chlormethiazole analogs, like its brominated derivative, 'bromethiazole' as I call it, for want of a better name, since it isn't used in medicine at all, that one is..well, a house specialty so to speak
, as there is a nice easy route to it, or chlormethiazole starting from vitamin B1, although the first step needs rigorous purification of the intermediate, as it starts with a bisulfite or metabisulfite cleavage of thiamine (vitamin B1) into two halves, one fragment, the 4-methylthiazole-2-ethanol portion then undergoes chlorination with SOCl2, and probably would work easily enough with something like disulfur dichloride, phosphorus trichloride or phosphorus pentachloride too, although SOCl2 works nice as the decomposition products, HCl and sulfur dioxide are both gaseous and can be removed super-easily from the reaction mixture. Its just the cleavage step has to be done with extreme caution in the purification, as the pyrimidine fragment of the B1 lysis reaction, its known as 'toxopyrimidine', and its a vitamin B6 antagonist, prevents GABA biosynthesis, making it a potent convulsant poison. Nasty shit, but removable with repeated ice-water washing, as its soluble in H2O whilst the methylthiazole-2-ethanol which serves as the intermediate to chlormethiazole or the brominated version, is poorly soluble in H2O, so the poisonous byproduct can be cleaned out, followed by, just for caution's sake, on my part, my performing a vacuum distillation on the intermediate alcohol.
I hope your dear lil royal cutie didn't suffer from the lack of meds either.
*warm well wishes for both of you*
Just took a sleeping pill tonight as well as the general night time meds, as again I feel sleepless. Going to munch down a can of cold rice pudding that I've been cooling down in the fridge, smoke my e-cig while I read some more of Vogels' fifth ed. practical organic chemistry book on the laptop, before it kicks in, munch a few candies, before it kicks in and I shove my blindfold on to go to sleep.
(I wear a blindfold to sleep, to keep the morning daylight away. Yuck. I don't like sunlight, and I like mornings even less. And morning AWAKENING by sunlight is just a filthy evil abortion which ought not to exist. Like that clapped out former hooker bitch in charge of giving head to...ahem...I mean, 'heading' autism squeaks. Whasserface, forgot her name, oh well, not important. She can always just be 'that nasty old slag from AutSqueaks' to me
Damn devil spawned NT whorebitch. Gross. How ANY male human being could ever have wanted HER disgusting NT arse naked in some tacky porno mag I will never know. Eww.
Now, time to sleep soon, while I stick some heavy music on nice and loud so I can sleep and get back to my chapter in Vogels', along with a small top up of my IR pain meds to avoid my hips hurting too much to lie down.
Did kinda want to get into some papers on asymmetric chiral iridium based hydrogenation catalysts for enantioselective hydrogenation of imines to amines at atmospheric pressure of hydrogen, but that'll have to wait for tomorrow.
