Might I ask, ren, what does moclobemide feel like, subjectively? on its own, I mean, does it possess the sort of stimulatory effects the irreversible, hydrazine style MAOIs are somewhat known for, I've experienced an MAOI before, although it was in the context of a yage' brew, where an MAOI allows for oral activity of DMT, using a plant admixture to supply both MAOI (in this case, Peganum harmala seed, for the harmaline and harmine as MAOIs, and the root-bark, extracted, of Mimosa hostilis for DMT)
It seems intriguing on its own, certainly the famous yage' vine of souls, Banisteriopsis caapi is well known as 'the light' IIRC amongst curanderos who use ayahuasca, about to go pick my med refill up again in a minute after I throw some clothes over me..
And..back, meds collected, just awaiting their taking effect, thankfully, the overheating I was suffering last night has been quelled by a combination of adrenolytic agents and opioidergics. Bugger me though, my temperature and heart rate had soared, and I was dripping wet sweating bullets, as the noradrenaline release inhibitors wore off and the pain meds wore down to intolerable levels for a while, as is wont to happen if I don't make some...alternative plans, for the wee small hours on the night before I pick up my refill, as by then, I've used everything up, and all meds are at their lowest plasma level possible, generally means I save at least some clonidine, and buy a couple of packs of co-codamol, and perform an extraction to rid them of the paracetamol, or better yet, their dihydrocodeine counterpart, the solubility of either being perfect in water, whilst APAP is nearly insoluble and forms a suspension, which either can be left to settle over time, or when I don't want to bugger about waiting, just grind 'em up, add ice cold water and subject it to vacuum filtration at the aspirator pump, sucks it through in a trice. Although it does mean having to give my nice clean fritted buchners a bath in nitric acid or something similar after to dispose of the residues that cling obstinately, ordinarily I'd use chromic acid, or possibly piranha acid (hydrogen peroxide and sulfuric acid, aka piranha bath, for the vicious tendencies it has and its insane hunger for anything vaguely organic, as well as potential to blow sky high with certain things, such as if idiots try using it to get rid of anything where acetone is present (acetone peroxide formation, in a bath of crazy vicious corrosive etch solution...not pretty, theres just no way a touchy as fuck shock-sensitive primary high explosive with a foul temper and an acid bath can get along, when the two are mixed together.
Its just...even the blind chemist would think 'bugger that for a lark' if they had any sense at all. But it has happened, and when realized, caused faculties to bail out on the area lest it go kablooey after some scmuck goes and ends up dumping liter quantities of acetone into piranha etch, and making enough TATP to blow the building to smithereens and more than enough to potentially detonate at any random time for such trivial reasons as internal stresses in a crystal, or a crystal growing large enough to detonate under its own weight, taking kilogram quantities of TATP with it, and blasting the piranha acid everywhere.
(I read a blog sometimes, and its hilarious the shitups undergrads get into like that. The sort of thing you just start reading and think 'oh this IS gonna end in tears', its like watching it unfold almost.
I especially like the peroxidized ether can in a fridge one, a salutatory lesson in keeping opened cans of ether regularly tested for peroxidation, this thing apparently had been forgotten in some fridge, peroxidized to high hell and back, and literally turned the fridge into a fragmentation bomb, blasting shrapnel made from fridge-bits through the ceiling, with half a fridge stuck in the roof, along with laying waste to the windows, all shattered by the overpressure of the shockwave when, thankfully when nobody was present, the ethylidene peroxide detonated spontaneously and nuked the fridge and lab. Ether peroxides are scary mothers, they form over time, and as little as a few milligrams is enough to shatter a flask and turn it into a storm of razor-edged shrapnel and tear a man to shreds if he be near it when it goes off (which it will, ethers form these peroxides and intermediate hydroperoxides, the latter aren't so bad, relatively speaking, as they deflagrate rather than detonate, but the alkylidene peroxides are INCREDIBLY sensitive, so much so that old cans of ether that get crusty, you NEVER open one, you don't even touch it, you just have to call the bomb squad, because its that shock and motion/friction sensitive, the slightest stress and it'll detonate with extreme violence, whilst solvated in a highly flammable solvent. Peroxides seem to cause a lot of those 'undergrad...issues'. That and tellurium, for its infamous tellurium breath. Something so foul, that people so afflicted, I read, have even taken their own lives after being rendered a complete pariah to anyone other than their fellow tellurium chemists.
Its akin to sweating, pissing, exhaling, shitting etc. and any other excretion methods included, of noxious sulfurous species if these be formed in vivo as a metabolite from something, only with tellurium, the stench is way worse than anything sulfur or even selenium is capable of, and people have, actually ended their own lives because it was that dreadful.
The sulfur version, the mildest possible incarnation, happened to me once, after my seizure med, I'd needed a lot of rescue doses, over several days and its based on a methylated thiazole ring, so something happened to it metabolically speaking, and for about a week to a week and a half, I couldn't walk down the street without people literally turning and running, when they came into about a 100 meter range upwind of me. Sweating it out, pissing it out, even TEAR fluid stank so terribly that even when I went to see a doctor about it, I was obliged to hide in the toilets rather than enter a waiting room, so heinous was the mercaptanesque stench that nobody could tolerate it.
Not much fun to have your nasal fluid impregnated with a hideous reek either haha.
And the chalcogens get worse. Where an oxygenated compound smells fine, the sulfur one often smells bad, sometimes really quite foul, the next chalcogen down, selenium gives rise to worse stenches still, and tellurium is the sort of chemistry you get somebody else to do, because you don't want to absorb the merest few micrograms to milligrams, as if you touch and absorb such a thing, it gets released as volatile alkyl and hydrogen tellurides in small quantities, and these smell so abysmally foul, and are so friggin potent, that a dead man would vomit if brought near them. And its well known for Te chemists to 'leave little presents' in books they take out at unis, the paper they touch reeks to hell's foulest depths, just from skin contact with minute traces of the organotellurium species. Chemist snark-off might include the term 'tellurium breath' as an insult, so legendary is the abominable reek Te absorption produces. A shame, since it is such a beautiful element, to look at, perhaps the most pretty of them all, bar radioactive glowing, its a metalloid, like silicon, germanium or arsenic, semi-metallic, and brittle rather than bendable, as sulfur is, but natural crystals have a real gorgeous look to them, especially growing off other natural crystal formations, as this intensely silvery white, faceted gem-like material.
Just look at this and tell me you wouldn't, if it had no foul properties, see it as a viable gemstone, albeit one of great delicacy, but surpassing beauty.
